Compound Detail
CHEMBL5188686
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Basic Information
| ChEMBL ID | CHEMBL5188686 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QUUYIUNMVCBKPD-HZSPNIEDSA-N |
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
259.4
MW (Da)
1.18
ALogP
4
HBA
4
HBD
72.7
PSA (Ų)
0.47
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 4.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acidic alpha-glucosidase CHEMBL3513 | IC50 | 4.18 | 4.18 | 66000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acidic alpha-glucosidase | IC50 | = | 66000.0 | nM | 4.18 | Inhibition of rat intestinal maltase assessed as release of D-glucose using malt... | 35255314 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35255314 | 10.1016/j.ejmech.2022.114230 | Unchecked | 11 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Acidic alpha-glucosidase | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Sucrase-isomaltase, intestinal | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Lysosomal alpha-glucosidase | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Alpha-galactosidase | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Alpha-mannosidase | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Tissue alpha-L-fucosidase | 1 |
Data from ChEMBL 36 via Core Engine