Compound Detail
CHEMBL5189044
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5189044 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SJAZZYOCOXNSIX-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
224.3
MW (Da)
2.50
ALogP
2
HBA
2
HBD
38.0
PSA (Ų)
0.73
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.72
Kd 1 meas. best 7.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucose-induced degradation protein 4 homolog CHEMBL5169174 | Kd | 7.77 | 7.77 | 17.0 | 1 |
| Glucose-induced degradation protein 4 homolog CHEMBL5169174 | IC50 | 4.72 | 4.72 | 18900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucose-induced degradation protein 4 homolog | Kd | = | 17.0 | nM | 7.77 | Binding affinity to GID4 (124 to 289) (unknown origin) assessed as dissociation ... | 36117290 |
| Glucose-induced degradation protein 4 homolog | IC50 | = | 18900.0 | nM | 4.72 | Inhibition of GID4 (124 to 289) (unknown origin) expressed in Escherichia coli B... | 36117290 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36117290 | 10.1021/acs.jmedchem.2c00509 | Glucose-induced degradation protein 4 homolog | 3 |
Data from ChEMBL 36 via Core Engine