Compound Detail
CHEMBL5192083
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Basic Information
| ChEMBL ID | CHEMBL5192083 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FAUJNJKIHJSYDO-BYNSBNAKSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
273.4
MW (Da)
1.43
ALogP
4
HBA
4
HBD
72.7
PSA (Ų)
0.48
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysosomal acid glucosylceramidase CHEMBL2179 | IC50 | 9.22 | 9.22 | 0.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysosomal acid glucosylceramidase | IC50 | = | 0.6 | nM | 9.22 | Inhibition of human GCase assessed as reduction of 4-methylumbelliferone liberat... | 35675756 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35675756 | 10.1016/j.ejmech.2022.114499 | Lysosomal acid glucosylceramidase | 1 |
Data from ChEMBL 36 via Core Engine