Compound Detail
CHEMBL5193580
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5193580 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ITEOZYPWUUMVMI-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
404.5
MW (Da)
3.53
ALogP
6
HBA
0
HBD
50.7
PSA (Ų)
0.65
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas.
Ki 1 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 6.22 | 6.22 | 602.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | Ki | = | 602.56 | nM | 6.22 | Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells me... | 35248836 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35248836 | 10.1016/j.ejmech.2022.114218 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 2 |
| 35248836 | 10.1016/j.ejmech.2022.114218 | 5-hydroxytryptamine receptor 1A | 1 |
| 35248836 | 10.1016/j.ejmech.2022.114218 | 5-hydroxytryptamine receptor 7 | 1 |
Data from ChEMBL 36 via Core Engine