Compound Detail
CHEMBL5194579
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Basic Information
| ChEMBL ID | CHEMBL5194579 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ACHNSUZRNPPIPW-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
277.4
MW (Da)
4.01
ALogP
2
HBA
0
HBD
20.3
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Eukaryotic elongation factor 2 kinase CHEMBL5026 | IC50 | 6.64 | 6.64 | 230.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Eukaryotic elongation factor 2 kinase | IC50 | = | 230.0 | nM | 6.64 | Inhibition of eEF2K (unknown origin) | 35483594 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35483594 | 10.1016/j.bmcl.2022.128759 | Eukaryotic elongation factor 2 kinase | 1 |
Data from ChEMBL 36 via Core Engine