Compound Detail
CHEMBL5194671
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CNC(=O)[C@]1(C)CC[C@@H](Nc2ncc3c(Br)nn(-c4ccc(-c5nnc(C)s5)c(CNS(C)(=O)=O)c4)c3n2)C1
Basic Information
| ChEMBL ID | CHEMBL5194671 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AGPSOQLCGIGKMT-OYLFLEFRSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
634.6
MW (Da)
3.17
ALogP
11
HBA
3
HBD
156.7
PSA (Ų)
0.26
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| eIF-2-alpha kinase GCN2 CHEMBL5358 | IC50 | 6.96 | 6.96 | 109.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| eIF-2-alpha kinase GCN2 | IC50 | = | 109.0 | nM | 6.96 | Inhibition of GCN2 (unknown origin) | 36127295 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36127295 | 10.1021/acs.jmedchem.2c00736 | eIF-2-alpha kinase GCN2 | 2 |
Data from ChEMBL 36 via Core Engine