Compound Detail
CHEMBL5195604
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CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(C)=O)[C@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C(C)C
Basic Information
| ChEMBL ID | CHEMBL5195604 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LVYIYYGXSDQMMQ-NUMDGUEPSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1765.1
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 9.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| B-cell lymphoma 6 protein CHEMBL4105786 | Kd | 9.22 | 9.11 | 0.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| B-cell lymphoma 6 protein | Kd | = | 0.6 | nM | 9.22 | Binding affinity to BCL6 BTB domain (unknown origin) by SPR analysis | 36441945 |
| B-cell lymphoma 6 protein | Kd | = | 1.0 | nM | 9.0 | Inhibition of FLAG tagged human BCL6 (5 to 129 residues) by ELISA | 36441945 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36441945 | 10.1021/acs.jmedchem.2c01433 | B-cell lymphoma 6 protein | 2 |
Data from ChEMBL 36 via Core Engine