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Compound Detail

CHEMBL5196051

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COc1ccc(S(=O)(=O)Nc2ccc(CN3CCN(C(=O)C4CC(O)(C(F)(F)F)C4)CC3)cc2)cc1

Basic Information

ChEMBL ID CHEMBL5196051
Phase Preclinical
Structure Type MOL
InChI Key BZEPMJKQJUMBSG-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
1
PK Parameters
3
Publications
0
Known Names

Molecular Properties

527.6
MW (Da)
2.84
ALogP
6
HBA
2
HBD
99.2
PSA (Ų)
0.57
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H28F3N3O5S
MW 527.57
Aromatic Rings 2
Heavy Atoms 36
NP-Likeness -1.26

Pharmacokinetic Data

Parameter Value Units Species
CL 8.0 mL.min-1.g-1 Mus musculus

Literature References

PubMed DOI Target Context # Activities
35594652 10.1016/j.ejmech.2022.114421 Trypanosoma cruzi 1
35594652 10.1016/j.ejmech.2022.114421 ADMET 1
35594652 10.1016/j.ejmech.2022.114421 No relevant target 1

Data from ChEMBL 36 via Core Engine