Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL5197721

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COCCCn1cc(CN(C(=O)[C@H]2CNCCO2)C2CC2)c2ccc(C)cc21

Basic Information

ChEMBL ID CHEMBL5197721
Phase Preclinical
Structure Type MOL
InChI Key IPWYLXUUEWIMPI-OAQYLSRUSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

385.5
MW (Da)
2.47
ALogP
5
HBA
1
HBD
55.7
PSA (Ų)
0.71
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H31N3O3
MW 385.51
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness -1.46

Activity Summary

IC50 2 meas. best 7.72

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Renin
CHEMBL286
IC50 7.72 7.425 19.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
35978678 10.1021/acsmedchemlett.2c00280 Renin 2

Data from ChEMBL 36 via Core Engine