Compound Detail
CHEMBL5203806
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CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(N)=O)[C@@H](C)O)C(C)C)C(=O)O)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL5203806 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DKRBRCIJWLUXIM-PRWHUYHMSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
3883.3
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 10.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor CHEMBL1784 | EC50 | 10.89 | 10.89 | 0.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 10.82 | 10.82 | 0.0 | 1 |
| Glucagon receptor CHEMBL1985 | EC50 | 10.77 | 10.77 | 0.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor | EC50 | = | 0.013 | nM | 10.89 | Agonist activity at human GLP1R expressed in frozen cells assessed as increase i... | 35978682 |
| Unchecked | EC50 | = | 0.015 | nM | 10.82 | Agonist activity at rhesus monkey GLP1R | 35978682 |
| Glucagon receptor | EC50 | = | 0.017 | nM | 10.77 | Agonist activity at human GCGR expressed in frozen cells assessed as increase in... | 35978682 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35978682 | 10.1021/acsmedchemlett.2c00217 | Unchecked | 4 |
| 35978682 | 10.1021/acsmedchemlett.2c00217 | Glucagon receptor | 1 |
| 35978682 | 10.1021/acsmedchemlett.2c00217 | Glucagon-like peptide 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine