Compound Detail
CHEMBL521300
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Basic Information
| ChEMBL ID | CHEMBL521300 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JQZRJAXQPHNNDU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
256.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 4 CHEMBL2093863 | IC50 | 5.57 | 5.57 | 2700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 4 | IC50 | = | 2700.0 | nM | 5.57 | Inhibition of PDE4 in human U937 cells assessed as accumulation of [3H]adenosine... | 19303290 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19303290 | 10.1016/j.bmcl.2009.03.007 | PBMC | 7 |
| 19303290 | 10.1016/j.bmcl.2009.03.007 | Phosphodiesterase 4 | 1 |
| 19303290 | 10.1016/j.bmcl.2009.03.007 | L929 | 1 |
Data from ChEMBL 36 via Core Engine