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Compound Detail

CHEMBL5220467

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C[C@@H](O)[C@@H]1NC(=O)[C@H]2NC(=O)[C@H](NC(=O)CN)CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(=O)O)NC1=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)c(I)c1)C(=O)N[C@@H](CCCN)C(=O)N[C@H](C(=O)N[C@H](CC(=O)N[C@@H](CCCN)C(=O)O)Cc1ccc(O)cc1)CSSC2(C)C

Basic Information

ChEMBL ID CHEMBL5220467
Phase Preclinical
Structure Type MOL
InChI Key QHPSFIKTRMNNLZ-TZHKBYJCSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

1831.9
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C70H107IN22O20S4
MW 1831.93

Activity Summary

IC50 1 meas. best 9.47

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuronal acetylcholine receptor; alpha9/alpha10
CHEMBL2109238
IC50 9.47 9.47 0.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
34142837 10.1021/acs.jmedchem.1c00512 Neuronal acetylcholine receptor; alpha9/alpha10 1

Data from ChEMBL 36 via Core Engine