Compound Detail
CHEMBL523605
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Basic Information
| ChEMBL ID | CHEMBL523605 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DYXUIRJHJRVUJH-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
425.4
MW (Da)
3.46
ALogP
5
HBA
1
HBD
79.4
PSA (Ų)
0.81
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 CHEMBL4794 | IC50 | 7.46 | 7.1533 | 35.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | IC50 | = | 35.0 | nM | 7.46 | Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells a... | 18722778 |
| Transient receptor potential cation channel subfamily V member 1 | IC50 | = | 100.0 | nM | 7.0 | Activation Assay: The functional activity of compounds at the TRPV1 receptor was... | - |
| Transient receptor potential cation channel subfamily V member 1 | IC50 | = | 100.0 | nM | 7.0 | Activation Assay: The cDNA for human TRPV1 (hTRPV1) was isolated by reverse tran... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18722778 | 10.1016/j.bmc.2008.08.005 | Rattus norvegicus | 2 |
| 18722778 | 10.1016/j.bmc.2008.08.005 | Transient receptor potential cation channel subfamily V member 1 | 1 |
Data from ChEMBL 36 via Core Engine