Compound Detail

CHEMBL524538

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CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc2c[nH]cn2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)C(C)C

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL524538
Phase	Preclinical
Structure Type	BOTH
InChI Key	PAMPKNPMNUNCAF-KXYXCEFHSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

3395.7

MW (Da)

Drug Information

Molecule Type	Protein
Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C152H228N42O47
MW	3395.74

Activity Summary

EC50 1 meas. best 9.35

IC50 1 meas. best 7.58

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Glucagon-like peptide 1 receptor CHEMBL1784	EC50	9.35	9.35	0.5	1
Glucagon-like peptide 1 receptor CHEMBL1784	IC50	7.58	7.58	26.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Glucagon-like peptide 1 receptor	EC50	=	0.45	nM	9.35	Agonist activity at human GLP1R expressed in CHO cells assessed as increase in c...	18412318
Glucagon-like peptide 1 receptor	IC50	=	26.0	nM	7.58	Displacement of [125I]GLP1 from human GLP1R expressed in CHOK1 cells	18412318

Literature References

PubMed	DOI	Target Context	# Activities
18412318	10.1021/jm701522b	Glucagon-like peptide 1 receptor	2

Data from ChEMBL 36 via Core Engine