Compound Detail
CHEMBL524664
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Basic Information
| ChEMBL ID | CHEMBL524664 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GXJABQQUPOEUTA-DOTOQJQBSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
384.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.16 | 6.16 | 700.0 | 1 |
| 20S proteasome CHEMBL3831201 | IC50 | 5.82 | 5.82 | 1524.0 | 1 |
| Lon protease homolog, mitochondrial CHEMBL4879436 | IC50 | 5.68 | 5.68 | 2111.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 700.0 | nM | 6.16 | Inhibition of chymotrypsin-like activity of human 20s proteasome beta 5 subunit ... | 19537716 |
| 20S proteasome | IC50 | = | 1524.0 | nM | 5.82 | Inhibition of human erythrocytes 20S proteasome using QXL520-YRGITCSGRQK(5-FAM)-... | 33821636 |
| Lon protease homolog, mitochondrial | IC50 | = | 2111.0 | nM | 5.68 | Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide... | 33821636 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23294826 | 10.1016/j.bmc.2012.11.045 | Gamma-secretase | 2 |
| 19537716 | 10.1021/jm9005093 | Unchecked | 1 |
| 33821636 | 10.1021/acs.jmedchem.0c02152 | Lon protease homolog, mitochondrial | 1 |
| 33821636 | 10.1021/acs.jmedchem.0c02152 | 20S proteasome | 1 |
Data from ChEMBL 36 via Core Engine