Compound Detail
CHEMBL526550
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C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](N)Cc2ccccc2)SS1)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL526550 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | OWUWTNRTKGNXIY-GINGGRPQSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
1004.2
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.67
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 4 CHEMBL1853 | IC50 | 6.67 | 6.67 | 214.0 | 1 |
| Somatostatin receptor type 2 CHEMBL1804 | IC50 | 6.47 | 6.47 | 337.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 4 | IC50 | = | 214.0 | nM | 6.67 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF28 from human sst4 receptor expr... | 18410083 |
| Somatostatin receptor type 2 | IC50 | = | 337.0 | nM | 6.47 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF28 from human sst2 receptor expr... | 18410083 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18410083 | 10.1021/jm701445q | Somatostatin receptor type 1 | 1 |
| 18410083 | 10.1021/jm701445q | Somatostatin receptor type 5 | 1 |
| 18410083 | 10.1021/jm701445q | Somatostatin receptor type 2 | 1 |
| 18410083 | 10.1021/jm701445q | Somatostatin receptor type 3 | 1 |
| 18410083 | 10.1021/jm701445q | Somatostatin receptor type 4 | 1 |
Data from ChEMBL 36 via Core Engine