Compound Detail
CHEMBL5266078
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Basic Information
| ChEMBL ID | CHEMBL5266078 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HXAODWZKEDXMRG-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
308.4
MW (Da)
2.20
ALogP
6
HBA
2
HBD
84.2
PSA (Ų)
0.75
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.66 | 6.66 | 220.0 | 1 |
| Glycogen synthase kinase-3 alpha CHEMBL2850 | IC50 | 6.29 | 6.29 | 510.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 220.0 | nM | 6.66 | Inhibition of N-terminal 6-His tagged human recombinant GSK3-beta H355L mutant u... | 36950863 |
| Glycogen synthase kinase-3 alpha | IC50 | = | 510.0 | nM | 6.29 | Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREI... | 36950863 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36950863 | 10.1021/acs.jmedchem.3c00133 | Unchecked | 1 |
| 36950863 | 10.1021/acs.jmedchem.3c00133 | Glycogen synthase kinase-3 alpha | 1 |
Data from ChEMBL 36 via Core Engine