Compound Detail
CHEMBL5271468
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Basic Information
| ChEMBL ID | CHEMBL5271468 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NUUWLGXOHGOZLE-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
390.5
MW (Da)
4.08
ALogP
5
HBA
4
HBD
100.3
PSA (Ų)
0.46
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 6.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 4 CHEMBL1853 | EC50 | 6.5 | 6.5 | 316.2 | 2 |
| Somatostatin receptor type 2 CHEMBL1804 | EC50 | 6.1 | 6.09 | 794.3 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 4 | EC50 | = | 316.23 | nM | 6.5 | Agonist activity at human SST4 receptor expressed in CHO-K1 cells assessed as in... | 36655128 |
| Somatostatin receptor type 4 | EC50 | = | 320.0 | nM | 6.5 | Agonist activity at human SST4 receptor expressed in CHO-K1 cells assessed as in... | 36655128 |
| Somatostatin receptor type 2 | EC50 | = | 794.33 | nM | 6.1 | Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as in... | 36655128 |
| Somatostatin receptor type 2 | EC50 | = | 840.0 | nM | 6.08 | Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as in... | 36655128 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36655128 | 10.1021/acsmedchemlett.2c00431 | Somatostatin receptor type 2 | 2 |
| 36655128 | 10.1021/acsmedchemlett.2c00431 | Somatostatin receptor type 4 | 2 |
Data from ChEMBL 36 via Core Engine