Compound Detail
CHEMBL5272365
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Basic Information
| ChEMBL ID | CHEMBL5272365 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IXDLWFQZQQBARS-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
264.3
MW (Da)
2.85
ALogP
4
HBA
0
HBD
52.6
PSA (Ų)
0.53
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| SF-188 CHEMBL614906 | IC50 | 4.12 | 4.12 | 76000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| SF-188 | IC50 | = | 76000.0 | nM | 4.12 | Antiproliferative activity against human SF-188 cells assessed as cell growth in... | 32679451 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32679451 | 10.1016/j.ejmech.2020.112628 | Astrocyte | 1 |
| 32679451 | 10.1016/j.ejmech.2020.112628 | U-251 | 1 |
| 32679451 | 10.1016/j.ejmech.2020.112628 | SF-188 | 1 |
Data from ChEMBL 36 via Core Engine