Compound Detail
CHEMBL5274307
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Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)C(C)(C)C)cc1
Basic Information
| ChEMBL ID | CHEMBL5274307 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RBXRNYWJBSBHDG-UVGSMQMLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1165.4
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| von Hippel-Lindau disease tumor suppressor CHEMBL3108660 | Kd | 7.96 | 7.96 | 11.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| von Hippel-Lindau disease tumor suppressor | Kd | = | 11.0 | nM | 7.96 | Binding affinity to human VHL by isothermal calorimetric assay | 35763424 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35763424 | 10.1021/acs.jmedchem.2c00728 | von Hippel-Lindau disease tumor suppressor | 3 |
Data from ChEMBL 36 via Core Engine