Compound Detail
CHEMBL5275342
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Basic Information
| ChEMBL ID | CHEMBL5275342 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZXBPREXLEPSERZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
250.2
MW (Da)
4.15
ALogP
3
HBA
2
HBD
53.6
PSA (Ų)
0.49
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | IC50 | 6.64 | 6.64 | 230.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 230.0 | nM | 6.64 | Inhibition of DYRK1A (unknown origin) | 30243157 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30243157 | 10.1016/j.ejmech.2018.08.093 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
Data from ChEMBL 36 via Core Engine