Compound Detail
CHEMBL5275871
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5275871 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DLHCOEMSRRHZLI-DDSCZMRISA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
347.4
MW (Da)
2.38
ALogP
7
HBA
2
HBD
94.2
PSA (Ų)
0.79
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 8.6 | 8.3825 | 2.5 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 2.5 | nM | 8.6 | Antimalarial activity against Plasmodium falciparum Dd2 | 33508479 |
| Plasmodium falciparum | IC50 | = | 2.8 | nM | 8.55 | Antimalarial activity against Plasmodium falciparum 3D7 | 33508479 |
| Plasmodium falciparum | IC50 | = | 6.1 | nM | 8.21 | Antimalarial activity against Plasmodium falciparum IPC5202 | 33508479 |
| Plasmodium falciparum | IC50 | = | 6.8 | nM | 8.17 | Antimalarial activity against Plasmodium falciparum IPC4912 | 33508479 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33508479 | 10.1016/j.ejmech.2021.113193 | Plasmodium falciparum | 4 |
Data from ChEMBL 36 via Core Engine