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Compound Detail

CHEMBL5276155

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COc1ccc(-c2nc3ccc(-c4ccc5n[se]nc5c4)cc3[nH]2)cc1

Basic Information

ChEMBL ID CHEMBL5276155
Phase Preclinical
Structure Type MOL
InChI Key QQAUZLDTNQGYLX-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

405.3
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H14N4OSe
MW 405.32

Activity Summary

IC50 1 meas. best 5.83

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
EJ
CHEMBL614292
IC50 5.83 5.83 1480.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
EJ IC50 = 1480.0 nM 5.83 Anticancer activity against human EJ cells assessed as cell growth inhibition in... 34217061

Literature References

PubMed DOI Target Context # Activities
34217061 10.1016/j.ejmech.2021.113621 EJ 1

Data from ChEMBL 36 via Core Engine