Compound Detail
CHEMBL5276548
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Basic Information
| ChEMBL ID | CHEMBL5276548 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LRGHMNBKDUXJAQ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
292.3
MW (Da)
2.03
ALogP
6
HBA
1
HBD
74.2
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.97
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 5.97 | 5.94 | 1060.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 1060.0 | nM | 5.97 | Antimalarial activity against Plasmodium falciparum RKL9 | 33508479 |
| Plasmodium falciparum | IC50 | = | 1240.0 | nM | 5.91 | Antimalarial activity against Plasmodium falciparum 3D7 | 33508479 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33508479 | 10.1016/j.ejmech.2021.113193 | Plasmodium falciparum | 2 |
Data from ChEMBL 36 via Core Engine