Compound Detail
CHEMBL5278223
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
N=C(N)NCCC[C@H](N)C(=O)NCC(=O)N[C@H](CCNC(=N)NCSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL5278223 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IPKVUIWZYZMQPU-NWWWNNGFSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
667.8
MW (Da)
-5.10
ALogP
15
HBA
13
HBD
356.4
PSA (Ų)
0.03
QED
3
Ro5 Violations
17
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.23
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.23 | 6.23 | 590.0 | 1 |
| Protein arginine N-methyltransferase 1 CHEMBL5524 | IC50 | 5.77 | 5.77 | 1700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 590.0 | nM | 6.23 | Inhibition of Trypanosoma brucei PRMT7 by fluorescence-based SAHH-coupled assay | 36274274 |
| Protein arginine N-methyltransferase 1 | IC50 | = | 1700.0 | nM | 5.77 | Inhibition of human PRMT1 by fluorescence-based SAHH-coupled assay | 36274274 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36274274 | 10.1016/j.ejmech.2022.114842 | Unchecked | 1 |
| 36274274 | 10.1016/j.ejmech.2022.114842 | Protein arginine N-methyltransferase 1 | 1 |
Data from ChEMBL 36 via Core Engine