Compound Detail
CHEMBL5279887
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Basic Information
| ChEMBL ID | CHEMBL5279887 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OVKHZAIDUQWQQU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
356.4
MW (Da)
4.66
ALogP
5
HBA
2
HBD
73.1
PSA (Ų)
0.49
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nuclear factor NF-kappa-B complex CHEMBL2094258 | EC50 | 8.05 | 8.05 | 9.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nuclear factor NF-kappa-B complex | EC50 | = | 9.0 | nM | 8.05 | Inhibition of NFkappaB in human Jurkat cells incubated for 30 mins by bright-glo... | 36490325 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36490325 | 10.1021/acs.jmedchem.2c00799 | Nuclear factor NF-kappa-B complex | 1 |
| 36490325 | 10.1021/acs.jmedchem.2c00799 | UBX domain-containing protein 11 | 1 |
Data from ChEMBL 36 via Core Engine