Compound Detail
CHEMBL5279978
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Basic Information
| ChEMBL ID | CHEMBL5279978 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DLQDTOXPYMCBJT-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
411.5
MW (Da)
4.58
ALogP
4
HBA
3
HBD
88.2
PSA (Ų)
0.45
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 4 CHEMBL1853 | EC50 | 8.3 | 8.28 | 5.0 | 2 |
| Somatostatin receptor type 2 CHEMBL1804 | EC50 | 7.2 | 7.2 | 63.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 4 | EC50 | = | 5.012 | nM | 8.3 | Agonist activity at human SST4 receptor expressed in CHO-K1 cells assessed as in... | 36655128 |
| Somatostatin receptor type 4 | EC50 | = | 5.5 | nM | 8.26 | Agonist activity at human SST4 receptor expressed in CHO-K1 cells assessed as in... | 36655128 |
| Somatostatin receptor type 2 | EC50 | = | 63.0 | nM | 7.2 | Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as in... | 36655128 |
| Somatostatin receptor type 2 | EC50 | = | 63.1 | nM | 7.2 | Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as in... | 36655128 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36655128 | 10.1021/acsmedchemlett.2c00431 | Somatostatin receptor type 2 | 2 |
| 36655128 | 10.1021/acsmedchemlett.2c00431 | Somatostatin receptor type 4 | 2 |
Data from ChEMBL 36 via Core Engine