Compound Detail
CHEMBL5280651
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CC[C@H](C)[C@H](NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1(N)CCC(c2ccccc2)CC1)C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL5280651 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VHPADIIFLPJJBT-BSUNUJMOSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1454.8
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proprotein convertase subtilisin/kexin type 9 CHEMBL2929 | IC50 | 6.85 | 6.505 | 140.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proprotein convertase subtilisin/kexin type 9 | IC50 | = | 140.0 | nM | 6.85 | Inhibition of human PCSK9 preincubated for 30 mins followed by ab20 addition and... | 36446632 |
| Proprotein convertase subtilisin/kexin type 9 | IC50 | = | 700.0 | nM | 6.16 | Inhibition of human PCSK9 | 36446632 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36446632 | 10.1021/acs.jmedchem.2c01290 | Proprotein convertase subtilisin/kexin type 9 | 2 |
Data from ChEMBL 36 via Core Engine