Compound Detail
CHEMBL5282576
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CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NCC(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)[C@@H](C)O
Basic Information
| ChEMBL ID | CHEMBL5282576 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IMZPOYFUQSTXPC-XMOOFPFESA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
4109.6
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 9.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor CHEMBL1075290 | EC50 | 9.35 | 9.35 | 0.5 | 1 |
| Glucagon receptor CHEMBL4773 | EC50 | 9.17 | 9.17 | 0.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor | EC50 | = | 0.45 | nM | 9.35 | Agonist activity at mouse GLP-1R expressed in CHO cells assessed as increase in ... | 32682196 |
| Glucagon receptor | EC50 | = | 0.68 | nM | 9.17 | Agonist activity at mouse GCGR expressed in CHO cells assessed as increase in cA... | 32682196 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32682196 | 10.1016/j.ejmech.2020.112496 | Glucagon receptor | 2 |
| 32682196 | 10.1016/j.ejmech.2020.112496 | Glucagon-like peptide 1 receptor | 2 |
Data from ChEMBL 36 via Core Engine