Compound Detail
CHEMBL5285412
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Basic Information
| ChEMBL ID | CHEMBL5285412 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OSQRDTGDOMJJLV-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
463.5
MW (Da)
4.05
ALogP
8
HBA
2
HBD
102.0
PSA (Ų)
0.44
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 6.92 | 6.73 | 120.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 120.0 | nM | 6.92 | Inhibition of human FLT3 D835Y mutant using TK peptide as substrate incubated fo... | 36638621 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 288.0 | nM | 6.54 | Inhibition of human wild type FLT3 using TK peptide as substrate incubated for 1... | 36638621 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36638621 | 10.1016/j.bmc.2023.117155 | Receptor-type tyrosine-protein kinase FLT3 | 2 |
Data from ChEMBL 36 via Core Engine