Compound Detail
CHEMBL5286814
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Basic Information
| ChEMBL ID | CHEMBL5286814 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZCLZOGZSLISYIY-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
379.5
MW (Da)
4.79
ALogP
6
HBA
0
HBD
60.0
PSA (Ų)
0.65
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 CHEMBL1875 | EC50 | 7.14 | 7.14 | 72.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | EC50 | = | 72.0 | nM | 7.14 | Partial agonist activity at human 5HT4E receptor expressed in CHO cells assessed... | 34251799 |
| 5-hydroxytryptamine receptor 4 | EC50 | = | 72.0 | nM | 7.14 | Cell-Based Assay: A stable CHO cell line expressing recombinant human 5-HT4 rece... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34251799 | 10.1021/acs.jmedchem.1c00703 | 5-hydroxytryptamine receptor 4 | 2 |
Data from ChEMBL 36 via Core Engine