Compound Detail
CHEMBL5290264
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5290264 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FUSYUJVUSOWKKS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
459.5
MW (Da)
5.15
ALogP
4
HBA
2
HBD
94.9
PSA (Ų)
0.40
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Induced myeloid leukemia cell differentiation protein Mcl-1 CHEMBL4361 | Ki | 5.77 | 5.77 | 1710.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Ki | = | 1710.0 | nM | 5.77 | Inhibition of FITC-labelled BAK BH3 peptide to 6His-MBP tagged recombinant human... | 36760746 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Ki | = | 1712.0 | nM | 5.77 | fluorescence polarization competition assay (FPCA): Molecular modeling and SILCS... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36760746 | 10.1039/d2md00277a | Induced myeloid leukemia cell differentiation protein Mcl-1 | 1 |
Data from ChEMBL 36 via Core Engine