Compound Detail
CHEMBL5291155
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5291155 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VUPIIHSYRDZCSU-ZWKOTPCHSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
353.4
MW (Da)
3.66
ALogP
3
HBA
1
HBD
45.2
PSA (Ų)
0.81
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| LSD1/CoREST complex CHEMBL3137262 | IC50 | 8.41 | 8.41 | 3.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| LSD1/CoREST complex | IC50 | = | 3.9 | nM | 8.41 | Inhibition of human recombinant LSD1/CoREST using ART(mK)QTARKSTGGKAPRKQLAGGK-bi... | 34423983 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34423983 | 10.1021/acs.jmedchem.1c00653 | ADMET | 2 |
| 34423983 | 10.1021/acs.jmedchem.1c00653 | LSD1/CoREST complex | 1 |
| 34423983 | 10.1021/acs.jmedchem.1c00653 | ATP-dependent translocase ABCB1 | 1 |
Data from ChEMBL 36 via Core Engine