Compound Detail
CHEMBL5308250
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Basic Information
| ChEMBL ID | CHEMBL5308250 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NPPMVTBTTJNVKP-CYBMUJFWSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
326.4
MW (Da)
2.61
ALogP
4
HBA
2
HBD
71.9
PSA (Ų)
0.90
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.13
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A CHEMBL3535 | IC50 | 5.13 | 5.13 | 7470.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | IC50 | = | 7470.0 | nM | 5.13 | Panlabs assay PDE9A2 | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL5303765 | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | 3 |
| - | 10.6019/CHEMBL5303765 | Calcium/calmodulin-dependent protein kinase type IV | 2 |
| - | 10.6019/CHEMBL5303765 | BMP-2-inducible protein kinase | 2 |
| - | 10.6019/CHEMBL5303765 | Aurora kinase B | 2 |
| - | 10.6019/CHEMBL5303765 | RAC-gamma serine/threonine-protein kinase | 2 |
| - | 10.6019/CHEMBL5303765 | Tyrosine-protein kinase ABL1 | 2 |
| - | 10.6019/CHEMBL5303765 | AP2-associated protein kinase 1 | 2 |
| - | 10.6019/CHEMBL5303765 | Bone morphogenetic protein receptor type-2 | 2 |
| - | 10.6019/CHEMBL5303765 | Cytoplasmic tyrosine-protein kinase BMX | 2 |
| - | 10.6019/CHEMBL5303765 | Calcium/calmodulin-dependent protein kinase type II subunit delta | 2 |
| - | 10.6019/CHEMBL5303765 | Cyclin-dependent kinase 2 | 2 |
| - | 10.6019/CHEMBL5303765 | Serine/threonine-protein kinase WNK1 | 2 |
| - | 10.6019/CHEMBL5303765 | Serine/threonine-protein kinase B-raf | 2 |
| - | 10.6019/CHEMBL5303765 | Calcium/calmodulin-dependent protein kinase type 1D | 2 |
| - | 10.6019/CHEMBL5303765 | Calcium/calmodulin-dependent protein kinase type II subunit beta | 2 |
| - | 10.6019/CHEMBL5303765 | Bromodomain-containing protein 4 | 2 |
| - | 10.6019/CHEMBL5303765 | Cell division control protein 42 homolog | 2 |
| - | 10.6019/CHEMBL5303765 | Cyclin-dependent kinase-like 1 | 2 |
| - | 10.6019/CHEMBL5303765 | Peregrin | 2 |
| - | 10.6019/CHEMBL5303765 | Calcium/calmodulin-dependent protein kinase type 1G | 2 |
Data from ChEMBL 36 via Core Engine