Compound Detail
CHEMBL5314462
FLIZASERTIB 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL5314462 |
| Name | FLIZASERTIB |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | LMXPZWQVDDSYHH-RYUDHWBXSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
7
Known Names
3
Indications
Molecular Properties
271.3
MW (Da)
2.87
ALogP
4
HBA
0
HBD
47.8
PSA (Ų)
0.81
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Autoimmune Diseases Graft vs Host Disease Inflammation
Activity Summary
Ki 2 meas. best 8.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-interacting serine/threonine-protein kinase 1 CHEMBL5464 | Ki | 8.44 | 8.27 | 3.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-interacting serine/threonine-protein kinase 1 | Ki | = | 3.6 | nM | 8.44 | Enzyme Assay: The ability of the receptor interacting protein kinase (RIPK1) to ... | - |
| Receptor-interacting serine/threonine-protein kinase 1 | Ki | = | 7.9 | nM | 8.1 | Enzyme Assay: The ability of the receptor interacting protein kinase (RIPK1) to ... | - |
Data from ChEMBL 36 via Core Engine