Compound Detail
CHEMBL5314926
RMC-5552 Phase I
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Phase I
CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)N3CCc4cc(Cn5nc(-c6ccc7oc(N)nc7c6)c6c(N)ncnc65)ccc4C3)[C@H](OC)C2)C[C@@H](O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C
Basic Information
| ChEMBL ID | CHEMBL5314926 |
| Name | RMC-5552 |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | IUTYTXDIGUNPAA-GKVGALOGSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
1
Known Names
2
Indications
Molecular Properties
1778.2
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Chirality | Single Enantiomer |
Indications
Glioblastoma Neoplasms
Activity Summary
IC50 3 meas. best 9.77
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| mTORC1 | IC50 | = | 0.17 | nM | 9.77 | Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K p... | 36533617 |
| mTORC1 | IC50 | = | 1.6 | nM | 8.8 | Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 ph... | 36533617 |
| Unchecked | IC50 | = | 35.0 | nM | 7.46 | Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in AKT phos... | 36533617 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36533617 | 10.1021/acs.jmedchem.2c01658 | mTORC1 | 2 |
| 36533617 | 10.1021/acs.jmedchem.2c01658 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine