Compound Detail
CHEMBL5395573
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CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(-c4ccc(OCCN5CCOCC5)cn4)sc23)c(F)c1
Basic Information
| ChEMBL ID | CHEMBL5395573 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AFBYRCBPMOJSTO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
725.8
MW (Da)
6.94
ALogP
11
HBA
1
HBD
117.0
PSA (Ų)
0.14
QED
3
Ro5 Violations
12
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage-stimulating protein receptor CHEMBL2689 | IC50 | 8.62 | 8.62 | 2.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage-stimulating protein receptor | IC50 | = | 2.39 | nM | 8.62 | Inhibition of N-terminal GST-tagged human recombinant RON (979 to 1400(end) resi... | 37736180 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37736180 | 10.1021/acsmedchemlett.3c00206 | HT-29 | 1 |
| 37736180 | 10.1021/acsmedchemlett.3c00206 | Macrophage-stimulating protein receptor | 1 |
| 37736180 | 10.1021/acsmedchemlett.3c00206 | KM12C | 1 |
| 37736180 | 10.1021/acsmedchemlett.3c00206 | SW-620 | 1 |
Data from ChEMBL 36 via Core Engine