Compound Detail
CHEMBL5400302
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CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC(F)F)nn2)c(=O)n3Cc2c(F)cccc2F)cc1
Basic Information
| ChEMBL ID | CHEMBL5400302 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GKSAUYOCWFXUSD-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
2
PK Parameters
3
Publications
0
Known Names
Molecular Properties
659.6
MW (Da)
4.34
ALogP
11
HBA
2
HBD
132.6
PSA (Ų)
0.17
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor CHEMBL1855 | IC50 | 9.59 | 9.135 | 0.3 | 2 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 5.51 | 5.51 | 3070.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 6.75 | mL.min-1.kg-1 | Homo sapiens |
| CL | 16.6 | mL.min-1.kg-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor | IC50 | = | 0.26 | nM | 9.59 | Displacement of [1251][D-Trp6]-LH-RH from human GnRH-R expressed in Chem-1 cells... | 35998545 |
| Gonadotropin-releasing hormone receptor | IC50 | = | 2.08 | nM | 8.68 | Antagonist activity at human GnRH-R expressed in HEK293 cells assessed as change... | 35998545 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 3070.0 | nM | 5.51 | Inhibition of human recombinant hERG expressed in CHO-K1 cells assessed as inhib... | 35998545 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35998545 | 10.1016/j.ejmech.2022.114679 | ADMET | 5 |
| 35998545 | 10.1016/j.ejmech.2022.114679 | Gonadotropin-releasing hormone receptor | 2 |
| 35998545 | 10.1016/j.ejmech.2022.114679 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine