Compound Detail
CHEMBL5402303
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Basic Information
| ChEMBL ID | CHEMBL5402303 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SMRFUMNKQVWJJK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
249.3
MW (Da)
1.97
ALogP
3
HBA
1
HBD
46.2
PSA (Ų)
0.83
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 4.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein cereblon CHEMBL3763008 | Ki | 4.89 | 4.89 | 13000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein cereblon | Ki | = | 13000.0 | nM | 4.89 | Binding affinity to human CRBN thalidomide binding domain assessed as inhibition... | 36476642 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36476642 | 10.1016/j.ejmech.2022.114990 | Protein cereblon | 1 |
| 36476642 | 10.1016/j.ejmech.2022.114990 | MOLP-8 | 1 |
| 36476642 | 10.1016/j.ejmech.2022.114990 | KMS-12-PE | 1 |
Data from ChEMBL 36 via Core Engine