Compound Detail
CHEMBL5403765
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Basic Information
| ChEMBL ID | CHEMBL5403765 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | APTHIEWSUULFSE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
309.3
MW (Da)
2.73
ALogP
4
HBA
2
HBD
84.1
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 8 CHEMBL5719 | IC50 | 6.85 | 6.85 | 142.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 8 | IC50 | = | 142.5 | nM | 6.85 | Inhibition of CDK8 (unknown origin) in presence of ATP by ADP-Glo assay | 36889252 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36889252 | 10.1016/j.ejmech.2023.115214 | Cyclin-dependent kinase 8 | 2 |
Data from ChEMBL 36 via Core Engine