Compound Detail
CHEMBL5404027
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CN1CCC(COc2ccn(-c3ccc(F)cc3)c(=O)c2C(=O)Nc2ccc(Oc3ccnc4cc(-c5ccc(CN6CCOCC6)cn5)sc34)c(F)c2)C1
Basic Information
| ChEMBL ID | CHEMBL5404027 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LRYALHYOWOCAED-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
764.9
MW (Da)
6.99
ALogP
11
HBA
1
HBD
111.0
PSA (Ų)
0.15
QED
3
Ro5 Violations
11
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage-stimulating protein receptor CHEMBL2689 | IC50 | 7.12 | 7.12 | 75.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage-stimulating protein receptor | IC50 | = | 75.62 | nM | 7.12 | Inhibition of N-terminal GST-tagged human recombinant RON (979 to 1400(end) resi... | 37736180 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37736180 | 10.1021/acsmedchemlett.3c00206 | Macrophage-stimulating protein receptor | 1 |
Data from ChEMBL 36 via Core Engine