Compound Detail
CHEMBL5405177
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Cc1cc([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C#CCOCCOCCOCCOCCNC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)cc2)C(C)C)on1
Basic Information
| ChEMBL ID | CHEMBL5405177 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YLFPZGFBGPLUOM-YIFYIKBSSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1094.8
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| von Hippel-Lindau disease tumor suppressor/Bromodomain-containing protein 4 CHEMBL4296140 | EC50 | 7.8 | 7.8 | 16.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| von Hippel-Lindau disease tumor suppressor/Bromodomain-containing protein 4 | EC50 | = | 16.0 | nM | 7.8 | PROTAC activity in VHL/BRD4 in human MV4-11 cells assessed as induction of BRD4 ... | 37224698 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37224698 | 10.1016/j.bmc.2023.117334 | von Hippel-Lindau disease tumor suppressor/Bromodomain-containing protein 4 | 1 |
Data from ChEMBL 36 via Core Engine