Compound Detail

CHEMBL5405626

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CC(=O)Nc1ccc(Nc2ncc3ccc(-c4cnc5c(c4C)NCCO5)cc3n2)cc1C

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL5405626
Phase	Preclinical
Structure Type	MOL
InChI Key	KXNZHHSQNDBDPV-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

440.5

MW (Da)

4.81

ALogP

HBA

HBD

101.1

PSA (Å²)

0.42

QED

Ro5 Violations

Rot. Bonds

Availability	Unknown
Chirality	Unknown

First in Class Prodrug

IC50 2 meas. best 9.7

EC50 1 meas. best 7.77

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Mitogen-activated protein kinase kinase kinase kinase 1 CHEMBL5749	IC50	9.7	9.11	0.2	2
Mitogen-activated protein kinase kinase kinase kinase 1 CHEMBL5749	EC50	7.77	7.77	17.0	1

Parameter	Value	Units	Species
CL	85.0	mL.min-1.kg-1	Mus musculus
F	6.5	%	Mus musculus

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Mitogen-activated protein kinase kinase kinase kinase 1	IC50	=	0.2	nM	9.7	Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infecte...	37531921
Mitogen-activated protein kinase kinase kinase kinase 1	IC50	=	3.0	nM	8.52	Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 ph...	37531921
Mitogen-activated protein kinase kinase kinase kinase 1	EC50	=	17.0	nM	7.77	Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-po...	37531921

PubMed	DOI	Target Context	# Activities
37531921	10.1016/j.bmc.2023.117423	ADMET	5
37531921	10.1016/j.bmc.2023.117423	Mitogen-activated protein kinase kinase kinase kinase 1	3
37531921	10.1016/j.bmc.2023.117423	No relevant target	2

Data from ChEMBL 36 via Core Engine