Compound Detail
CHEMBL5409389
NT-0796 Phase I
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Phase I
Basic Information
| ChEMBL ID | CHEMBL5409389 |
| Name | NT-0796 |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | UMUQEMHROZVOTF-LJQANCHMSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
15
Publications
1
Known Names
1
Indications
Molecular Properties
409.5
MW (Da)
3.57
ALogP
6
HBA
1
HBD
90.4
PSA (Ų)
0.73
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Cardiovascular Diseases
Activity Summary
IC50 3 meas. best 9.49
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NACHT, LRR and PYD domains-containing protein 3 CHEMBL1741208 | IC50 | 9.49 | 8.7733 | 0.3 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NACHT, LRR and PYD domains-containing protein 3 | IC50 | = | 0.32 | nM | 9.49 | Inhibition of NLRP3 inflammasome activation in LPS-activated human PBMC cells as... | 37874905 |
| NACHT, LRR and PYD domains-containing protein 3 | IC50 | = | 2.1 | nM | 8.68 | Inhibition of NLRP3 inflammasome activation in LPS-induced human THP-1 cells exp... | 37874905 |
| NACHT, LRR and PYD domains-containing protein 3 | IC50 | = | 7.0 | nM | 8.15 | Inhibition of NLRP3 inflammasome activation in human whole blood assessed as inh... | 37874905 |
Literature References
Data from ChEMBL 36 via Core Engine