Compound Detail
CHEMBL5410111
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Basic Information
| ChEMBL ID | CHEMBL5410111 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XXFAZAVSEGUCQE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
308.3
MW (Da)
3.18
ALogP
4
HBA
2
HBD
75.3
PSA (Ų)
0.78
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone acetyltransferase KAT8 CHEMBL1932912 | IC50 | 4.57 | 4.57 | 26900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone acetyltransferase KAT8 | IC50 | = | 26900.0 | nM | 4.57 | Inhibition of N-terminal 6His tagged KAT8 (173 to 458 residues) (unknown origin)... | 37155735 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37155735 | 10.1021/acs.jmedchem.2c01937 | Histone acetyltransferase KAT8 | 1 |
| 37155735 | 10.1021/acs.jmedchem.2c01937 | Histone acetyltransferase p300 | 1 |
| 37155735 | 10.1021/acs.jmedchem.2c01937 | Histone acetyltransferase KAT2B | 1 |
Data from ChEMBL 36 via Core Engine