Compound Detail
CHEMBL5412037
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CC(C)C[C@H](NC(=O)C(NC(=O)c1cc(C(F)(F)F)ccc1C(F)(F)F)C1CCCC1)B(O)O
Basic Information
| ChEMBL ID | CHEMBL5412037 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LUTJDSKZCOIFQI-BHWOMJMDSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
496.3
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 20S proteasome CHEMBL3831201 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
| RPMI-8226 CHEMBL614882 | IC50 | 8.16 | 8.16 | 6.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 20S proteasome | IC50 | = | 6.0 | nM | 8.22 | Inhibition of human 20S proteasome chymotrypsin-like activity using Suc-Leu-Leu-... | 36806958 |
| RPMI-8226 | IC50 | = | 6.9 | nM | 8.16 | Cytotoxicity against human RPMI-8226 cells assessed as inhibition of cell prolif... | 36806958 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36806958 | 10.1016/j.ejmech.2023.115187 | 20S proteasome | 1 |
| 36806958 | 10.1016/j.ejmech.2023.115187 | RPMI-8226 | 1 |
Data from ChEMBL 36 via Core Engine