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Compound Detail

CHEMBL541290

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COc1cc([C@@H]2c3cc4c(cc3[C@@H](CCN(C)N(C)c3ccccc3)C3COC(=O)[C@@H]32)OCO4)cc(OC)c1O.Cl

Basic Information

ChEMBL ID CHEMBL541290
Phase Preclinical
Structure Type MOL
InChI Key WQTVCOAPNUWJII-WCSCJQKSSA-N
Parent Compound CHEMBL1190623
Active Moiety CHEMBL1190623
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

546.6
MW (Da)
4.53
ALogP
9
HBA
1
HBD
89.9
PSA (Ų)
0.32
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H35ClN2O7
MW 583.08
Aromatic Rings 3
Heavy Atoms 40
NP-Likeness 0.79

Literature References

PubMed DOI Target Context # Activities
8389875 10.1021/jm00064a002 P388 1
8389875 10.1021/jm00064a002 Tubulin 1
8389875 10.1021/jm00064a002 Unchecked 1

Data from ChEMBL 36 via Core Engine