Compound Detail
CHEMBL5417234
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5417234 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MHHVBPCYYCUVPT-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
251.3
MW (Da)
3.11
ALogP
2
HBA
1
HBD
21.3
PSA (Ų)
0.84
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C CHEMBL225 | EC50 | 7.0 | 6.9933 | 100.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | EC50 | = | 100.0 | nM | 7.0 | Partial agonist activity at human 5-HT2CR expressed in human Flp-In-T-REx-293 ce... | 38229745 |
| 5-hydroxytryptamine receptor 2C | EC50 | = | 103.1 | nM | 6.99 | Partial agonist activity at human 5-HT2CR expressed in human Flp-In-T-REx-293 ce... | 38229745 |
| 5-hydroxytryptamine receptor 2C | EC50 | = | 103.0 | nM | 6.99 | Agonist activity at recombinant human 5-HT2C stably expressed in human T-REx-293... | 37172474 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38229745 | 10.1021/acsmedchemlett.3c00454 | 5-hydroxytryptamine receptor 2C | 3 |
| 37172474 | 10.1016/j.ejmech.2023.115414 | 5-hydroxytryptamine receptor 2C | 2 |
| 38229745 | 10.1021/acsmedchemlett.3c00454 | 5-hydroxytryptamine receptor 2B | 1 |
| 38229745 | 10.1021/acsmedchemlett.3c00454 | 5-hydroxytryptamine receptor 2A | 1 |
| 38229745 | 10.1021/acsmedchemlett.3c00454 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine