Compound Detail
CHEMBL5418559
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Basic Information
| ChEMBL ID | CHEMBL5418559 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ISJMGGZLKGIAFX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
188.3
MW (Da)
2.37
ALogP
1
HBA
2
HBD
41.8
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 2.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Son of sevenless homolog 2 CHEMBL4524041 | Kd | 2.7 | 2.7 | 2000000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Son of sevenless homolog 2 | Kd | = | 2000000.0 | nM | 2.7 | Binding affinity to biotinylated SOS2 (unknown origin) by surface plasmon resona... | 38156904 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38156904 | 10.1021/acs.jmedchem.3c02140 | No relevant target | 1 |
| 38156904 | 10.1021/acs.jmedchem.3c02140 | Son of sevenless homolog 1 | 1 |
| 38156904 | 10.1021/acs.jmedchem.3c02140 | Son of sevenless homolog 2 | 1 |
Data from ChEMBL 36 via Core Engine