Compound Detail
CHEMBL5419628
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Basic Information
| ChEMBL ID | CHEMBL5419628 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UWHUYKGCGHNLEP-GFCCVEGCSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
366.4
MW (Da)
3.32
ALogP
4
HBA
1
HBD
54.4
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelial PAS domain-containing protein 1 CHEMBL1744522 | IC50 | 4.8 | 4.8 | 16000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelial PAS domain-containing protein 1 | IC50 | = | 16000.0 | nM | 4.8 | Inhibition of HIF-2alpha transcriptional activity in human 786-0 cells transfect... | 37403966 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37403966 | 10.1021/acs.jmedchem.3c00332 | Endothelial PAS domain-containing protein 1 | 1 |
Data from ChEMBL 36 via Core Engine